Publications

Publications

Our team is dedicated to sharing our research findings with the broader scientific community through publications in leading academic journals. Click here to access a list of our recent publications and learn more about our contributions to the field of sleep medicine.

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2024

 

  • Gileles-Hillel, A., Bhattacharjee, R., Gorelik, M. & Narang, I. Advances in Sleep-Disordered Breathing in Children. Clin. Chest Med. 45, 651–662 (2024).
  • Guzikevits, M. et al. Sex bias in pain management decisions. Proc. Natl. Acad. Sci. U. S. A. 121, (2024).
  • Levin, S., Mayer, D., Puius, Y. A., Arora, S. & Gileles-Hillel, A. Things We Do for No ReasonTM: Routine respiratory pathogen panels for emergency department and hospitalized patients. J. Hosp. Med. (2024) doi:10.1002/jhm.13365.
  • Yelov, L., Reiter, J., Cruz, M. M. E. & Gileles-Hillel, A. The association of obstructive sleep apnea and behavioral insomnia in children ages 10 and under. J. Clin. Sleep Med. 20, 245–251 (2024).

 

2023

 

  • Cohen-Cymberknoh, M. et al. Changes in Sleep in Children and Adults with Cystic Fibrosis and Primary Ciliary Dyskinesia over Time and after CFTR Modulator Therapy. J. Clin. Med. 12, (2023).
  • Sadras, I. et al. Clinical and functional efficacy of elexacaftor/tezacaftor/ivacaftor in people with cystic fibrosis carrying the N1303K mutation. J. Cyst. Fibros. 22, 1062–1069 (2023).
  • Adler-Haltovsky, T., Gileles-Hillel, A., Erlichman, I. & Eventov-Friedman, S. Changes in ventilation modes in the last decade and their impact on the prevalence of bronchopulmonary dysplasia in preterm infants. Pediatr. Pulmonol. 58, 1959–1966 (2023).
  • Reiter, J. et al. Sleep disorders in children with celiac disease: a prospective study. J. Clin. Sleep Med. 19, 591–594 (2023).
  • Gileles-Hillel, A. et al. The clinical yield of bronchoscopy in the management of cystic fibrosis: A retrospective multicenter study. Pediatr. Pulmonol. 58, 500–506 (2023).

 

2022

 

  • Dahan, T. et al. Chronic Intermittent Hypoxia during Sleep Causes Browning of Interscapular Adipose Tissue Accompanied by Local Insulin Resistance in Mice. Int. J. Mol. Sci. 23, (2022).
  • Gileles-Hillel, A. et al. The utility of glucose area under the curve from the oral glucose tolerance test as a screening tool for cystic fibrosis-related diabetes. Pediatr. Pulmonol. 57, 2774–2780 (2022).
  • Reiter, J., Breuer, O., Cohen-Cymberknoh, M., Forno, E. & Gileles-Hillel, A. Sleep in children with cystic fibrosis: More under the covers. Pediatr. Pulmonol. 57, 1944–1951 (2022).
  • Reiter, J., Ramagopal, M., Gileles-Hillel, A. & Forno, E. Sleep disorders in children with asthma. Pediatr. Pulmonol. 57, 1851–1859 (2022).
  • Choshen-Hillel, S. et al. Physicians prescribe fewer analgesics during night shifts than day shifts. Proc. Natl. Acad. Sci. U. S. A. 119, (2022).
  • Gileles-Hillel, A. & Dahan, T. Intermittent by day, sustained by night - the worst of both hypoxias? Sleep 45, (2022).
  • Israeli, T. et al. Respiratory physiotherapy in patients with cystic fibrosis and upper limb deep vein thrombosis. Pediatr. Pulmonol. 57, 1552–1554 (2022).
  • Biro, O., Gileles-Hillel, A., Dor-Wollman, T., Eisenstein, E. M. & Berkun, Y. Neurological and neurodevelopmental symptoms in children with familial Mediterranean fever and their siblings. Eur. J. Pediatr. 181, 973–978 (2022).

 

2021

 

  • van der Vaart, J. et al. Modelling of primary ciliary dyskinesia using patient-derived airway organoids. EMBO Rep. 22, (2021).
  • Choshen-Hillel, S. & Gileles-Hillel, A. A wake-up call: Time to raise physicians’ awareness of the consequences of fatigue. Med. Educ. 55, 1342–1344 (2021).
  • Paltiel, O. et al. Academic activism on behalf of children during the COVID-19 pandemic in Israel; beyond public health advocacy. Isr. J. Health Policy Res. 10, (2021).
  • Bar-Or, R. L. et al. Associations of exposure to nitrogen oxides with prevalent asthma and other atopic diseases in Israel. Environ. - MDPI 8, (2021).
  • Khalyfa, A. et al. Heterogeneity of melanoma cell responses to sleep apnea-derived plasma exosomes and to intermittent hypoxia. Cancers (Basel). 13, (2021).
  • Grunewald, M. et al. Counteracting age-related VEGF signaling insufficiency promotes healthy aging and extends life span. Science 373, (2021).
  • Kaditis, A. G. et al. Effects of the COVID-19 lockdown on sleep duration in children and adolescents: A survey across different continents. Pediatr. Pulmonol. 56, 2265–2273 (2021).
  • Cohen-Cymberknoh, M. et al. How abnormal is the normal? Clinical characteristics of CF patients with normal FEV1. Pediatr. Pulmonol. 56, 2007–2013 (2021).
  • Barak-Corren, Y., Barak-Corren, N., Gileles-Hillel, A. & Heiman, E. The effect of C-reactive protein on chest X-ray interpretation: A decision-making experiment among pediatricians. Pediatr. Pulmonol. 56, 1644–1650 (2021).
  • Gileles-Hillel, A. et al. Betamethasone versus dexamethasone for inpatient preschool wheezing—A case-control study. Pediatr. Pulmonol. 56, 875–882 (2021).
  • Raz, R. et al. Associations between exposure to industrial air pollution and prevalence of asthma and atopic diseases in haifa bay area. Atmosphere (Basel). 12, (2021).
  • Kerem, E. et al. Ivacaftor in People with Cystic Fibrosis and a 3849110kb C→T or D1152H Residual Function Mutation. Ann. Am. Thorac. Soc. 18, 433–441 (2021).
  • Gileles-Hillel, A. Sickle cell disease and obstructive sleep apnea-bad news for the brain. Sleep 44, (2021).
  • Choshen-Hillel, S. et al. Acute and chronic sleep deprivation in residents: Cognition and stress biomarkers. Med. Educ. 55, 174–184 (2021).
  • Mandelkorn, U. et al. Escalation of sleep disturbances amid the COVID-19 pandemic: A cross-sectional international study. J. Clin. Sleep Med. 17, 45–53 (2021).

 

2020

 

  • Ryan, S. et al. Understanding the pathophysiological mechanisms of cardiometabolic complications in obstructive sleep apnoea: Towards personalised treatment approaches. Eur. Respir. J. 56, (2020).
  • Yogev, D. et al. Hijab pin ingestions. Pediatrics 145, (2020).
  • Reiter, J. et al. Sleep disorders in cystic fibrosis: A systematic review and meta-analysis. Sleep Med. Rev. 51, (2020).
  • Gileles-Hillel, A. et al. Whole-exome sequencing accuracy in the diagnosis of primary ciliary dyskinesia. ERJ Open Res. 6, (2020).
  • Lavi, E., Gileles-Hillel, A. & Zangen, D. Somatic growth in cystic fibrosis. Curr. Opin. Endocrinol. Diabetes Obes. 27, 38–46 (2020).

 

2019

 

  • Sadras, I. et al. Prematurity as a risk factor of sleep-disordered breathing in children younger than two years: A retrospective case-control study. J. Clin. Sleep Med. 15, 1731–1736 (2019).
  • Gross, I. et al. Giant lung cysts following necrotizing pneumonia: Resolution with conservative treatment. Pediatr. Pulmonol. 54, 901–906 (2019).
  • Cohen-Cymberknoh, M., Atia, O., Gileles-Hillel, A., Kerem, E. & Reiter, J. Sleep disorders in patients with primary ciliary dyskinesia, cystic fibrosis with and without pancreatic insufficiency. Respir. Med. 151, 96–101 (2019).
  • Palma, J.-A., Gileles-Hillel, A., Norcliffe-Kaufmann, L. & Kaufmann, H. Chemoreflex failure and sleep-disordered breathing in familial dysautonomia: Implications for sudden death during sleep. Auton. Neurosci. Basic Clin. 218, 10–15 (2019).
  • Lavi, E. et al. Pyogenic sacroiliitis in children: don’t forget the very young. Eur. J. Pediatr. 178, 575–579 (2019).
  • Gileles-Hillel, A., Erlichman, I. & Reiter, J. Apnea of Prematurity: An Update. J. Child Sci. 9, E50–E58 (2019).

 

2017

 

  • Khalyfa, A. et al. Exosomes and metabolic function in mice exposed to alternating dark-light cycles mimicking night shift work schedules. Front. Physiol. 8, (2017).
  • Khalyfa, A. et al. Activation of the integrated stress response and metabolic dysfunction in a murine model of sleep apnea. Am. J. Respir. Cell Mol. Biol. 57, 477–486 (2017).
  • Cohen-Cymberknoh, M. et al. Clinical impact of Pseudomonas aeruginosa colonization in patients with Primary Ciliary Dyskinesia. Respir. Med. 131, 241–246 (2017).
  • Gozal, D. et al. Visceral white adipose tissue after chronic intermittent and sustained hypoxia in mice. Am. J. Respir. Cell Mol. Biol. 56, 477–487 (2017).
  • Gileles-Hillel, A. et al. Prolonged exposures to intermittent hypoxia promote visceral white adipose tissue inflammation in a murine model of severe sleep apnea: Effect of normoxic recovery. Sleep 40, (2017).
  • Cortese, R. et al. Aorta macrophage inflammatory and epigenetic changes in a murine model of obstructive sleep apnea: Potential role of CD36. Sci. Rep. 7, (2017).
  • Akbarpour, M. et al. Altered CD8+ t-cell lymphocyte function and tc1 cell stemness contribute to enhanced malignant tumor properties in murine models of sleep apnea. Sleep 40, (2017).
  • Gemel, J. et al. Intermittent hypoxia causes NOX2-dependent remodeling of atrial connexins. BMC Cell Biol. 18, (2017).

 

2016

 

  • Almendros, I. et al. Tumor Cell Malignant Properties Are Enhanced by Circulating Exosomes in Sleep Apnea. Chest 150, 1030–1041 (2016).
  • Poroyko, V. A. et al. Chronic Sleep Disruption Alters Gut Microbiota, Induces Systemic and Adipose Tissue Inflammation and Insulin Resistance in Mice. Sci. Rep. 6, (2016).
  • Khalyfa, A., Gileles-Hillel, A. & Gozal, D. The Challenges of Precision Medicine in Obstructive Sleep Apnea. Sleep Med. Clin. 11, 213–226 (2016).
  • Gileles-Hillel, A., Kheirandish-Gozal, L. & Gozal, D. Biological plausibility linking sleep apnoea and metabolic dysfunction. Nat. Rev. Endocrinol. 12, 290–298 (2016).
  • Khalyfa, A. et al. Circulating exosomes potentiate tumor malignant properties in a mouse model of chronic sleep fragmentation. Oncotarget 7, 54676–54690 (2016).

 

2015

 

  • Gileles-Hillel, A., Kheirandish-Gozal, L. & Gozal, D. Hemoglobinopathies and sleep - The road less traveled. Sleep Med. Rev. 24, 57–70 (2015).
  • Gileles-Hillel, A. et al. Association of chronic Candida albicans respiratory infection with a more severe lung disease in patients with cystic fibrosis. Pediatr. Pulmonol. 50, 1082–1089 (2015).
  • Alkhouri, N. et al. Evaluation of circulating markers of hepatic apoptosis and inflammation in obese children with and without obstructive sleep apnea. Sleep Med. 16, 1031–1035 (2015).
  • Kheirandish-Gozal, L. et al. Effects of adenotonsillectomy on plasma inflammatory biomarkers in obese children with obstructive sleep apnea: A community-based study. Int. J. Obes. 39, 1094–1100 (2015).
  • Gileles-Hillel, A., Philby, M. F. & Lapping-Carr, G. Insights into selected aspects of pediatric sleep medicine. Am. J. Respir. Crit. Care Med. 191, 1459–1461 (2015).
  • Almendros, I. et al. Adipose tissue macrophage polarization by intermittent hypoxia in a mouse model of OSA: Effect of tumor microenvironment. Cancer Lett. 361, 233–239 (2015).

 

2014

 

  • Carreras, A. et al. Chronic sleep fragmentation induces endothelial dysfunction and structural vascular changes in mice. Sleep 37, 1817–1824 (2014).
  • Gileles-Hillel, A. et al. Early intermittent hypoxia induces proatherogenic changes in aortic wall macrophages in a murine model of obstructive sleep apnea. Am. J. Respir. Crit. Care Med. 190, 958–961 (2014).
  • Gileles-Hillel, A. et al. Inflammatory markers and obstructive sleep apnea in obese children: The NANOS study. Mediators Inflamm. 2014, (2014).
  • Cohen-Cymberknoh, M. et al. Differences in disease expression between primary ciliary dyskinesia and cystic fibrosis with and without pancreatic insufficiency. Chest 145, 738–744 (2014).

 

2013

 

  • Milgrom, Y., Goldman, G., Gileles Hillel, A., Pojurovsky, S. & Ackerman, Z. Tuberculosis: A rare cause of peri-anal disease. Isr. Med. Assoc. J. 15, 782–783 (2013).
  • Simanovsky, N., Gileles-Hillel, A., Frenkel, R., Shosayov, D. & Hiller, N. Correlation between computed tomography expression of pulmonary hypertension and severity of lung disease in cystic fibrosis patients. J. Thorac. Imaging 28, 383–387 (2013).
  • Hiller, N., Schor-Bardach, R., Gileles-Hillel, A., Stroumsa, D. & Simanovsky, N. CT appearance of the pelvis after Cesarean delivery-what is considered normal? Clin. Imaging 37, 514–519 (2013).
  • Simanovsky, N. et al. Differences in the pattern of structural abnormalities on CT scan in patients with cystic fibrosis and pancreatic sufficiency or insufficiency. Chest 144, 208–214 (2013).