We are dedicated to advancing the fields of sleep and pulmonary research through interdisciplinary collaboration and innovative methodologies.

Sleep Apnea and Glucose Metabolism

Obstructive sleep apnea (OSA) is strongly and independently associated with impaired glucose metabolism and an increased risk of diabetes. In this line of research, we aim to unravel the connection between intermittent hypoxia during sleep—a hallmark feature of OSA—and the development of insulin resistance. Our studies focus on the cellular and molecular mechanisms through which intermittent hypoxia disrupts glucose homeostasis. Understanding these pathways will provide critical insights into how OSA contributes to metabolic dysfunction and may uncover potential therapeutic targets to mitigate these effects. 

Gileles-Hillel, A., Kheirandish-Gozal, L. & Gozal, D. Biological plausibility linking sleep apnoea and metabolic dysfunction. Nat Rev Endocrinol 12, 290–298 (2016).

Sleep Apnea and Cancer

Obstructive sleep apnea (OSA) is a well-established risk factor for the development of various cancers, including melanoma and breast cancer. In this line of research, in collaboration with Prof. Rinat Abramovitch, we are investigating the effects of intermittent and sustained hypoxic exposure—both in vivo and in vitro—on the malignant properties of colorectal cancer. Our goal is to elucidate the complex influence of OSA on cancer development and progression.

Colorectal Cancer load in mice exposed to room air (left) or intermittent hypoxia (right).

Organoids as a model for Respiratory Research

Airway organoids are advanced three-dimensional cell culture systems that replicate the structure and function of the human airway. These models offer a powerful platform to study various respiratory conditions by mimicking the physiological and pathological features of the airway. Previously, we utilized patient-specific airway organoids to model primary ciliary dyskinesia (PCD), providing valuable insights into disease mechanisms and potential therapeutic strategies. Currently, we are leveraging this technology to model asthma, aiming to deepen our understanding of its pathophysiology and advance personalized medicine approaches tailored to individual patients' needs.

Sleep, Psychology, and Decision-Making

In collaboration with researchers from the Hebrew University of Jerusalem (HUJI) Shoham Choshen-Hillel and Anat Perry, we are investigating the intricate connections between sleep, psychology, and decision-making. Our field and laboratory experiments examine the fundamental mechanisms influencing cognition and emotion during sleep. This work aims to uncover how sleep modulates cognitive processes and emotional states, with significant implications for mental health and performance in both clinical contexts and everyday life. The importance of this research has grown in the aftermath of the COVID-19 pandemic and, more recently, following the October 7th conflict involving Hamas. By studying the effects of these major stressors on healthcare professionals and the general population, we aim to understand how disrupted sleep impacts cognitive functions and emotional well-being during crises.